abstract：:Crystal-storing histiocytosis is an uncommon form of nonneoplastic histiocytic proliferation that in most patients complicates an underlying lymphoproliferative or plasma cell disorder. Lung is a common site of involvement in patients with localized disease. We present an illustrative example from a 54-year-old woman ...

journal_title：Archives of pathology & laboratory medicine

authors： Zhang C,Myers JL

更新日期：2013-09-01 00:00:00

abstract：CONTEXT:In 2006, the department of pathology at our institution established an intramural research funding mechanism to support anatomic pathology research projects for faculty and trainee development. A review committee consisting of faculty members with diverse academic interests evaluated applications; proposals wer...

journal_title：Archives of pathology & laboratory medicine

authors： McDaniel A,Fullen DR,Cho KR,Lucas DR,Giordano TJ,Greenson J,Lieberman AP,Kunju LP,Myers JL,Roh MH

更新日期：2013-09-01 00:00:00

abstract：CONTEXT:The clinical validity of mucin expression in gastric cancer is debated. Whereas several reports demonstrate a correlation between mucin expression and prognosis, others deny such an association. OBJECTIVES:This survival analysis study aims to elucidate the prognostic significance of mucin expression in gastric...

journal_title：Archives of pathology & laboratory medicine

authors： Kim DH,Shin N,Kim GH,Song GA,Jeon TY,Kim DH,Lauwers GY,Park DY

更新日期：2013-08-01 00:00:00

abstract：CONTEXT:Myofibroblastic proliferations of the urinary bladder, which share some similarities with nodular fasciitis, were first reported in 1980. Since then, they have had several designations, the most frequently used being inflammatory myofibroblastic tumor. Based on both histopathologic and prognostic grounds, some ...

journal_title：Archives of pathology & laboratory medicine

authors： Alquati S,Gira FA,Bartoli V,Contini S,Corradi D

更新日期：2013-08-01 00:00:00

abstract：CONTEXT:Several developments in genitourinary pathology are likely to change our understanding and management of some genitourinary cancers considerably. OBJECTIVE:To review 5 stories in genitourinary pathology: (1) fusion in the ETS (E26) gene family in prostatic adenocarcinoma; (2) insulin-like growth factor II mess...

journal_title：Archives of pathology & laboratory medicine

authors： Zhou AG,Owens CL,Cosar EF,Jiang Z

更新日期：2013-07-01 00:00:00

abstract：CONTEXT:Bone marrow examination is essential for diagnosis and staging of hematologic disorders. Traditionally, the bone marrow biopsy and aspirate are obtained with 2 needles at 2 separate sites. This approach is associated with significant discomfort, procedural time, and occasionally, morbidity. Although previous ob...

journal_title：Archives of pathology & laboratory medicine

authors： Al-Ibraheemi A,Pham T,Chen L,Syklawer E,Quesada A,Wahed A,Nedelcu E,Nguyen AN

更新日期：2013-07-01 00:00:00

abstract：CONTEXT:Within the continent of Africa few countries have been able to practice pathology at the levels present in Europe and the Americas, and pediatric pathology does not exist as a stand-alone specialty. The author was invited by a colleague from Harvard Medical School, Boston, Massachusetts, to join a group of Nort...

journal_title：Archives of pathology & laboratory medicine

authors： Kaschula RO

更新日期：2013-06-01 00:00:00

abstract：CONTEXT:The College of American Pathologists (CAP) Human Papillomavirus (High-Risk) Survey for Cytopathology and Other Laboratories (CHPV) meets the Clinical Laboratory Improvement Amendments of 1988 (CLIA '88) requirements for 5 proficiency testing challenges analyzed 3 times per year. This study reports laboratory pe...

journal_title：Archives of pathology & laboratory medicine

authors： Moriarty AT,Bentz JS,Winkler B,Fischer AH,Laucirica R,Souers RJ,Thomas N,Zhao C

更新日期：2013-05-01 00:00:00

abstract：CONTEXT:Diagnostic use of immunohistochemistry has been extensively studied in prostate needle biopsy, but its use in routine practice and the quality assurance and associated cost have not been previously addressed. OBJECTIVE:To examine the routine use of immunohistochemistry in prostate biopsies in a tertiary academ...

journal_title：Archives of pathology & laboratory medicine

authors： Watson K,Wang C,Yilmaz A,Bismar TA,Trpkov K

更新日期：2013-04-01 00:00:00

abstract：CONTEXT:Plasma cell myeloma and chronic lymphocytic leukemia are both common hematologic malignancies, sharing many epidemiologic features. Concomitant detection of the 2 conditions poses special diagnostic challenges for the pathologist. OBJECTIVE:To describe the pathologic findings in cases of concomitant bone marro...

journal_title：Archives of pathology & laboratory medicine

authors： Alley CL,Wang E,Dunphy CH,Gong JZ,Lu CM,Boswell EL,Burchette J,Lagoo AS

更新日期：2013-04-01 00:00:00

abstract：CONTEXT:No study has evaluated radiology/pathology correlation of percentage viable tumor (PVT) estimates in ablated hepatocellular carcinoma (HCC) to examine the reliability of radiologic estimates. OBJECTIVE:To determine how well interdisciplinary PVT estimates correlate and identify pathologic factors that influenc...

journal_title：Archives of pathology & laboratory medicine

authors： Hanson JA,Ason R,Weinreb J,Van Dyke A,Mitchell KA

更新日期：2013-03-01 00:00:00

abstract：CONTEXT:Implementation of proficiency testing for gynecologic cytology was delayed 20 years because of challenges addressing the subjective nature of cytologic interpretation and replicating normal working conditions. Concern remains regarding test scoring, slide validation, test environment, and other issues. How thes...

journal_title：Archives of pathology & laboratory medicine

authors： Howell LP,Nayar R,Savaloja L,Tabbara S,Thomas N,Winkler B,Tworek J

更新日期：2013-02-01 00:00:00

abstract：CONTEXT:Lung cancer is the number one cause of cancer deaths in the United States and globally. The advent of targeted therapies has offered a new treatment paradigm for lung cancer, but currently validated and emerging drugs are effective in only a small minority of lung cancers, predominantly adenocarcinomas. Folate ...

journal_title：Archives of pathology & laboratory medicine

authors： Cagle PT,Zhai QJ,Murphy L,Low PS

更新日期：2013-02-01 00:00:00

abstract：CONTEXT:As demand for organs to treat end-stage liver disease increases, donor livers once deemed only marginally suitable for donation are being considered for transplantation. Pathologists are increasingly being asked to evaluate these livers for acceptability. This article provides guidelines for frozen section eval...

journal_title：Archives of pathology & laboratory medicine

authors： Melin C,Miick R,Young NA,Ortiz J,Balasubramanian M

更新日期：2013-02-01 00:00:00

abstract：CONTEXT:In the United States, a successful vaccination program for hepatitis A virus (HAV) infection has decreased both its incidence and the true positive rate for diagnostic immunoglobulin M (IgM) antibody to HAV in acute hepatitis. OBJECTIVE:To survey positive results of HAV IgM tests and determine the effect of ch...

journal_title：Archives of pathology & laboratory medicine

authors： Alatoom A,Ansari MQ,Cuthbert J

更新日期：2013-01-01 00:00:00

abstract：CONTEXT:The advent of genotype-based therapy and predictive biomarkers for lung cancer has thrust the pathologist into the front lines of precision medicine for this deadly disease. OBJECTIVE:To provide the clinical background, current status, and future perspectives of molecular targeted therapy for lung cancer patie...

journal_title：Archives of pathology & laboratory medicine

authors： Cagle PT,Allen TC

更新日期：2012-12-01 00:00:00

abstract：CONTEXT:The role of pathologists' assistants (PAs) in terms of surgical and autopsy prosection has been well established; however, the role of PAs in areas beyond surgical and autopsy pathology, such as laboratory administration and management, education, and research, is not so well understood. OBJECTIVE:To determine...

journal_title：Archives of pathology & laboratory medicine

authors： Vitale J,Brooks R,Sovocool M,Rader WR

更新日期：2012-12-01 00:00:00

abstract：CONTEXT:There are virtually no data in the literature regarding the incidence, patterns, and clinicopathologic characteristics of mucinous carcinomas (MCs) of the gallbladder (GB). OBJECTIVE:To determine the incidence of mucinous differentiation in invasive GB carcinomas and the clinicopathologic characteristics of th...

journal_title：Archives of pathology & laboratory medicine

authors： Dursun N,Escalona OT,Roa JC,Basturk O,Bagci P,Cakir A,Cheng J,Sarmiento J,Losada H,Kong SY,Ducato L,Goodman M,Adsay NV

更新日期：2012-11-01 00:00:00

abstract：CONTEXT:In the 19th and early 20th centuries, cancer was defined by the demonstration of invasion and metastases, based upon gross findings at surgery or autopsy. Although histopathologic examination of tumors became possible with greater and greater resolution over time, the definition of cancer remained the same. Tum...

journal_title：Archives of pathology & laboratory medicine

authors： Wright JR Jr

更新日期：2012-11-01 00:00:00

abstract：CONTEXT:Mutation status of the KRAS gene identifies a distinct disease subtype of metastatic colorectal carcinoma that does not respond to antibody therapeutics targeting the epidermal growth factor receptor. This is currently the only validated marker in metastatic colorectal carcinoma with a clear implication in trea...

journal_title：Archives of pathology & laboratory medicine

authors： Ross JS

更新日期：2012-10-01 00:00:00

abstract：:Precision medicine is altering the traditional role of the surgical pathologist in caring for patients with lung cancer. Diagnosing specific cell type is now a foundation for selecting lung cancers for predictive-biomarker testing by molecular techniques. Using conventional techniques and familiar equipment, the surgi...

journal_title：Archives of pathology & laboratory medicine

authors： Cagle PT,Myers J

更新日期：2012-10-01 00:00:00

abstract：:Thoracic manifestations of rheumatic disease (RD) are increasingly recognized as a significant cause of morbidity and mortality worldwide. Rheumatologic underpinnings have been identified in a significant proportion of patients with interstitial lung disease. The 5 RDs most frequently associated with pleuropulmonary d...

journal_title：Archives of pathology & laboratory medicine

authors： Schneider F,Gruden J,Tazelaar HD,Leslie KO

更新日期：2012-10-01 00:00:00

abstract：:New Frontiers in Pathology is a unique educational event intended to meet the ongoing educational needs of practicing pathologists. Continuous medical education (CME) is required for maintenance of licensure by virtually all state licensing bodies. Satisfying CME requirements hinges on earning a minimum number of Amer...

journal_title：Archives of pathology & laboratory medicine

authors： Myers JL,Greenson JK

更新日期：2012-08-01 00:00:00

abstract：:Teratoid hepatoblastoma is a rare histologic subtype accounting for 4% to 10% of all hepatoblastomas and is characterized by the presence of divergent differentiation, including squamous, mucinous, melanocytic, cartilaginous, osseous, skeletal muscle, and neural elements. It is postulated that the teratoid elements mi...

journal_title：Archives of pathology & laboratory medicine

authors： Rabah R

更新日期：2012-08-01 00:00:00

abstract：CONTEXT:The skeletal system may be affected by a variety of nonneoplastic lesions, which may potentially be confused with primary bone tumors on clinical, radiologic, and pathologic grounds. These conditions include fractures, infections, and reactive and degenerative processes, as well as an array of quasineoplastic e...

journal_title：Archives of pathology & laboratory medicine

authors： Remotti F,Feldman F

更新日期：2012-07-01 00:00:00

abstract：CONTEXT:Micropapillary urothelial carcinoma (MPUC) is a known aggressive variant of urothelial carcinoma. However, the reasons for its aggressiveness remain unclear. OBJECTIVE:To investigate the frequency of lymphovascular invasion in 22 cases of MPUC. DESIGN:Consecutive tissue sections were stained with D2-40 and CD...

journal_title：Archives of pathology & laboratory medicine

authors： McQuitty E,Ro JY,Truong LD,Shen SS,Zhai Q,Ayala AG

更新日期：2012-06-01 00:00:00

abstract：:Amplification of the human epidermal growth factor receptor 2/neu (HER2/neu) gene and overexpression of the HER2 protein (HER2) have been shown to occur in gastric and gastroesophageal junction adenocarcinoma in a number of studies. With a dismal survival rate, patients with these cancers stand to benefit from the ide...

journal_title：Archives of pathology & laboratory medicine

authors： Hechtman JF,Polydorides AD

更新日期：2012-06-01 00:00:00

abstract：CONTEXT:Multiphoton microscopy (MPM) is a nonlinear imaging approach, providing cellular and subcellular details from fresh (unprocessed) tissue by exciting intrinsic tissue emissions. With miniaturization and substantially decreased cost on the horizon, MPM is an emerging imaging technique with many potential clinical...

journal_title：Archives of pathology & laboratory medicine

authors： Jain M,Robinson BD,Scherr DS,Sterling J,Lee MM,Wysock J,Rubin MA,Maxfield FR,Zipfel WR,Webb WW,Mukherjee S

更新日期：2012-05-01 00:00:00

abstract：CONTEXT:The inhibition of oncogenic kinase signaling is a successful strategy to treat both hematologic and solid malignancies. Patients with chronic myelogenous leukemia, lung adenocarcinoma, renal cell carcinoma, and gastrointestinal stromal tumors are experiencing tremendous clinical benefits from targeted therapies...

journal_title：Archives of pathology & laboratory medicine

authors： Marrari A,Wagner AJ,Hornick JL

更新日期：2012-05-01 00:00:00

abstract：CONTEXT:Our understanding of molecular events in the pathogenesis of hematologic malignancies has evolved substantially. The research data gathered in the past 3 decades have led to the definition of neoplastic disorders based on specific genetic and molecular alterations, which is reflected in the current World Health...

journal_title：Archives of pathology & laboratory medicine

authors： Pozdnyakova O,Kutok JL,Rodig SJ

更新日期：2012-05-01 00:00:00

abstract：CONTEXT:The unprecedented advances in cancer genetics and genomics are rapidly affecting clinical management and diagnostics in solid tumor oncology. Molecular diagnostics is now an integral part of routine clinical management in patients with lung, colon, and breast cancer. In sharp contrast, molecular biomarkers have...

journal_title：Archives of pathology & laboratory medicine

authors： Netto GJ,Cheng L

更新日期：2012-04-01 00:00:00

abstract：CONTEXT:Diagnosing epithelioid serosal lesions remains a challenge because numerous different processes-primary or secondary, benign or malignant-occur in body cavities, some of which are very rare. OBJECTIVES:To review the newest literature and to describe the morphologic criteria and immunohistochemical markers that...

journal_title：Archives of pathology & laboratory medicine

authors： Anttila S

更新日期：2012-03-01 00:00:00

abstract：:Metastatic Crohn disease is a rare cutaneous disorder characterized by noncaseating, granulomatous skin lesions present at sites anatomically separate from the gastrointestinal tract. It is the least common dermatologic manifestation of Crohn disease, and the differential diagnosis includes numerous similarly appearin...

journal_title：Archives of pathology & laboratory medicine

authors： Siroy A,Wasman J

更新日期：2012-03-01 00:00:00

abstract：:In this time of significant change in pathology and medicine, pathology's future is uncertain. Many issues, including the emergence of molecular medicine, the demand for personalized medicine, confusing payment schemes, increasing governmental regulation, medical education challenges, administrative relationships, and...

journal_title：Archives of pathology & laboratory medicine

authors： Allen TC

更新日期：2012-02-01 00:00:00

abstract：:Silicone, commonly used in cosmetic procedures owing to its presumed inertness, can yield serious sequelae including acute embolization and pneumonitis. Chronic pulmonary sequelae in response to silicone injection have not been previously described. We report a case of chronic progressive granulomatous pneumonitis in ...

journal_title：Archives of pathology & laboratory medicine

authors： Hariri LP,Gaissert HA,Brown R,Ciaranello A,Greene RE,Selig MK,Kradin RL

更新日期：2012-02-01 00:00:00

abstract：CONTEXT:Recent randomized controlled trials have shown a significant decrease in unsatisfactory rates for liquid-based cytology (LBC) compared with conventional Papanicolaou test (CP). The underlying causes and relevance of unsatisfactory results for LBC and CP have never been compared within the setting of a randomize...

journal_title：Archives of pathology & laboratory medicine

authors： Siebers AG,Klinkhamer PJ,Vedder JE,Arbyn M,Bulten J

更新日期：2012-01-01 00:00:00

abstract：CONTEXT:Two recent studies have identified a high rate of microsatellite instability (MSI) in pancreatic neuroendocrine tumors (pNETs). Microsatellite instability is rare in small intestinal neuroendocrine tumors (NETs). It is unclear why there is discordance in the frequency of MSI in the 2 studies of pNETs and why th...

journal_title：Archives of pathology & laboratory medicine

authors： Arnason T,Sapp HL,Rayson D,Barnes PJ,Drewniak M,Nassar BA,Huang WY

更新日期：2011-12-01 00:00:00

abstract：CONTEXT:A Treatise on Pathological Anatomy, published in 1829 by William E. Horner, is the first American textbook on pathology. Several articles have been written on Horner, but they do not evaluate the role that the knowledge he recorded played on the intellectual origin of the discipline of pathology in America. Onl...

journal_title：Archives of pathology & laboratory medicine

authors： Quinonez G,McLendon WW

更新日期：2011-12-01 00:00:00

abstract：CONTEXT:Methods to improve surgical pathology patient safety include measuring the frequency of error in specific steps of the surgical pathology testing process, root cause analysis of active and latent components, and implementation of quality improvement initiatives. OBJECTIVE:To determine the frequency and cause o...

journal_title：Archives of pathology & laboratory medicine

authors： Smith ML,Raab SS

更新日期：2011-11-01 00:00:00

abstract：:A 54-year-old woman presented with a nasal mass. Biopsy demonstrated undifferentiated tumor cells with extensive apoptosis and necrosis. Chromosome analysis identified a 46,XX,t(15;19)(q13;p13.1) pattern. Nuclear protein in testis (NUT) immunohistochemistry and fluorescence in situ hybridization confirmed NUT rearrang...

journal_title：Archives of pathology & laboratory medicine

authors： Davis BN,Karabakhtsian RG,Pettigrew AL,Arnold SM,French CA,Brill YM

更新日期：2011-11-01 00:00:00